Manufactured / Recombinant antigens
DESIGNED & MADE IN HOUSERecombinant antigens
Designed, expressed and purified by our own team in Cambridge. When native material is scarce, inconsistent or ethically difficult to obtain, a defined recombinant gives you a supply you can rely on lot after lot.
- In house
- Design to purification
- mg–g
- Scale to order
- Same lot
- Repeat supply
Why recombinant
What it solves
Native antigen from donor material is finite, variable between lots, and sometimes simply unavailable at the titre you need.
Consistency
A defined sequence expressed the same way every time. Your calibrator does not drift between lots.
Supply security
No dependence on donor availability or seasonal collection windows.
Scarce targets
Emerging pathogens and rare variants where clinical material barely exists.
Ethical simplicity
No donor consent chain, no human-derived handling requirements downstream.
Process
Designed to your target
Each antigen is designed and made for your target, construct, scale and format.
Custom antigens: from sequence to vial
Construct design
Target selection, epitope mapping and codon optimisation, worked out from your assay requirement.
Expression
System chosen to suit the target: bacterial for simple constructs, mammalian or insect where glycosylation and folding matter.
Purification
Affinity and polishing chromatography to the purity your application requires.
Characterisation
Purity, identity, concentration and activity confirmed before release, with data supplied on the Certificate of Analysis.
Formulation and fill
Buffer, concentration and fill volume to your specification, with the lot reserved for repeat supply.
Specification
What ships with each lot
Tell us the purity, format and scale your assay needs and we will confirm what is achievable before you commit. Looking for native material instead? See human serum and plasma or synthetic disease state plasma.
For your application
Matching format to purpose
Assay development
A defined construct means the epitope stays fixed while you optimise everything else around it.
Calibrators
Concentration is set exactly, so your standard curve doesn't drift between production lots.
Positive controls
Consistent supply independent of donor availability — reorder the same specification repeatedly.
Immunogens
Purity and formulation adjustable to suit the immunisation protocol.
Antibody screening
A stable reference antigen lets you compare antibody performance across batches on a fixed target.
Lateral flow
Scale and buffer compatibility discussed upfront, since flow format is sensitive to both.
Common questions
Before you enquire
Can you make the antigen we need?
Yes. Custom design is how we work. Send us the target and the application and we will come back with a proposed construct and expression approach.
Can you match a native antigen we already use?
Often, yes. Send us the current material and its performance data and we will design toward equivalence, then compare side by side before you switch.
Tell us your target
Sequence, application, purity and scale. We will tell you what is achievable and what it costs.